A T Hughes Selected Research

nitisinone (Orfadin)

6/2022	Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.
3/2022	Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria.
11/2019	Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria.
5/2019	Correction to: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
1/2019	Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
10/2018	Data on items of AKUSSI in Alkaptonuria collected over three years from the United Kingdom National Alkaptonuria Centre and the impact of nitisinone.
1/2018	Assessment of the Effect of Once Daily Nitisinone Therapy on 24-h Urinary Metadrenalines and 5-Hydroxyindole Acetic Acid Excretion in Patients with Alkaptonuria After 4 Weeks of Treatment.
1/2018	Serum Amino Acid Profiling in Patients with Alkaptonuria Before and After Treatment with Nitisinone.
1/2018	Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre.
1/2018	Asymptomatic Corneal Keratopathy Secondary to Hypertyrosinaemia Following Low Dose Nitisinone and a Literature Review of Tyrosine Keratopathy in Alkaptonuria.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

A T Hughes Research Topics

Disease

12	Alkaptonuria 06/2022 - 07/2014
2	Body Weight (Weight, Body) 06/2022 - 11/2019
2	Ochronosis 10/2018 - 01/2018
2	Disease Progression 01/2018 - 01/2018
1	Weight Gain 06/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2018
1	Alkaptonuric ochronosis 01/2018
1	Asthma (Bronchial Asthma) 12/2000

Drug/Important Bio-Agent (IBA)

11	nitisinone (Orfadin)FDA Link 06/2022 - 01/2018
7	Tyrosine (L-Tyrosine)FDA Link 06/2022 - 07/2014
4	Homogentisic AcidIBA 11/2019 - 01/2018
2	Urea (Carbamide)FDA LinkGeneric 06/2022 - 11/2019
2	Neurotransmitter Agents (Neurotransmitter)IBA 05/2019 - 01/2019
1	Phenylalanine (L-Phenylalanine)FDA Link 06/2022
1	Proteins (Proteins, Gene)FDA Link 06/2022
1	CreatinineIBA 06/2022
1	PolymersIBA 10/2018
1	5-hydroxyindoleIBA 01/2018
1	Amino Acids FDA Link 01/2018
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2018
1	anti-IgE antibodiesIBA 12/2000

Therapy/Procedure

3	Therapeutics 01/2018 - 01/2018
1	Protein-Restricted Diet (Diet, Protein Restricted) 06/2022
1	Slit Lamp 01/2018
1	Aftercare (After-Treatment) 01/2018